HPTLC plays a crucial role in the cleaning strategy at Sanofi’s API production site in Aramon, France. This method, applicable for cleaning production plants globally, is detailed in the case study “Cleaning validation at API production units”.

The team from CSIC, Instituto de Carboquímica, in Zaragoza, Spain, utilized HPTLC to investigate monoacylglycerides in biodiesel and blended diesel fuel. This method is crucial for ensuring compliance with European standards and for in-process control during biodiesel production.

HPTLC enables the simultaneous analysis of multiple samples, often with little to no sample preparation. This makes it a high-throughput technique that is both time-efficient and cost-effective. Additionally, HPTLC allows for the evaluation of a plate at any stage of the analytical process and the use of various detection modes, such as UV and fluorescence, in sequence when necessary.

The quality of raw materials directly impacts the success of chemical manufacturing. HPTLC provides an effective method for the identification and verification of raw materials, ensuring that only high-quality inputs are used in production. This helps to prevent costly errors or contamination in downstream processes.

HPTLC is highly efficient at separating and identifying organic compounds, making it ideal for analyzing chemicals such as polymers, surfactants, dyes, and pigments. By detecting and quantifying these components, HPTLC supports the development of new chemical formulations and quality control of existing products.

Detecting impurities in chemical formulations is crucial for both safety and performance. HPTLC enables the identification and quantification of trace impurities in raw materials or final products, helping manufacturers maintain product purity and comply with regulatory requirements.

In chemical synthesis, monitoring reaction progress is essential for optimizing production and ensuring consistent quality. HPTLC allows chemists to track the conversion of reactants to products in real-time, providing a quick and reliable way to ensure reactions are proceeding as expected.

Many chemical processes require additives or catalysts to enhance performance or efficiency. HPTLC is effective at analyzing the presence and concentration of these additives, ensuring they are used at optimal levels for the desired chemical outcomes.

The chemical industry must adhere to strict environmental regulations. HPTLC helps detect and quantify harmful substances, such as pollutants and by-products, ensuring compliance with environmental standards. This is crucial in reducing the environmental impact of chemical manufacturing and ensuring sustainable practices.