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CAM_TLC-MS_Interface-2

CAMAG®
TLC-MS Interface 2

Seamless integration of HPTLC and Mass Spectrometry for precise, rapid analysis.
CAM_TLC-MS_Interface-2

In a nutshell

Substance identification and confirmation

The TLC-MS Interface 2 enables rapid, contamination-free elution of TLC/HPTLC zones with direct transfer to any mass spectrometer. Its plug-and-play design integrates seamlessly with any LC-MS system, providing substance identification in under a minute via mass spectrum, or sum formula determination for unknown substances.

Zones are eluted using methanol or compatible solvents, with round and oval elution heads for circular and band-shaped zones, respectively. The eluate can be directly transferred for analysis or collected for further investigation with techniques like NMR and FTIR.

Key features include a modified elution head, an easily replaceable filter, and compressed air cleaning to prevent blockages and extend system life. The integrated crosshair laser and positioning tools ensure precise, reproducible plate alignment, with optional support from TLC Visualizer 3 or TLC Scanner 4.

  • Rapid and contamination-free elution of selected
  • Direct transfer to any mass spectrometer
  • Plug & play installation
  • Substance confirmation within a minute
  • Any plate format up to 20 x 20 cm

Application example

Characterization of separated compounds by Mass Spectrometry (Steviol glycosides in Stevia formulations*)
  • A.
    Chromatogram for localizing the zones (derivatized with ß-naphtol reagent)
  • B.
    HPTLC plate after elution of zones with the TLC-MS Interface 2
  • C.
    HPTLC-ESI-MS spectra of Rebaudioside A, m/z 989.6 [M+Na]+

* Morlock et al., Journal of Chromatography A, 1350 (2014) 102–111

Technical specifications

  • Plate types
    TLC/HPTLC glass plates and aluminium foils of sizes up to 20 x 20 cm and layer thickness up to 300 μm
  • Standard flow rate
    50–300 μL/min
  • Downforce
    max. 400 N
  • Gas supply pressure
    4–6 bar compressed air or N2
  • Laser type
    5 mW, laser class 1
  • Electrical power
    Two batteries 1.5 V, AA/LR6 size
  • Battery duration
    Up to 100 hours
  • Chemical Data
  • Elution head capillaries
    Stainless steel passivated and rinsed with reagent-grade methanol
  • Frit
    2 μm stainless steel
  • Elution head
    Stainless steel
  • Dimensions (W x D x H):
    275 x 425 x 275 mm
  • Weight
    14.5 kg

What you need to get started

Ordering Information

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Related documents

Download manuals for in-depth device guidance
Instruction Manual TLC-MS Interface 2
July 17, 2023
Declaration of Conformity TLC-MS Interface 2
February 15, 2021
Installation of Push Start for MS data acquisition
April 25, 2017
Replacement of TLC-MS Interface 2 elution head
January 14, 2016
Brochure TLC-MS Interface 2
June 8, 2017

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