Alox
CAMAG manufactures various types of Aluminium Oxide
Due to its amphoteric nature, CAMAG can produce Aluminum Oxide with a pH range from basic to acidic, offering various activity levels, with the driest form being the most active.
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Basic
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Neutral
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Weakly acidic
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Acidic
Purification Processes
Preparative Column Chromatography
is a widely used technique to separate and purify substances at lab scale, at pilot scale or even at production scale as substrate in chromatographic columns.
Flash Chromatography
is a rapid form of preparative column chromatography. Compared to preparative column chromatography focusing on purity, flash chromatography is mainly used as a pre-purification step to purify large sample quantities at a decent resolution. Flash chromatography is a simple and economical approach to preparative chromatography.
Selective Filtration
Recommended type of Aluminium Oxide
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Application
pH | activity | field of application
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Alkaloids
Basic | medium activity | isolation of ergot-, opium-, rauwolfia-, and other alkaloids
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Antibiotics
Neutral | highly active | isolation, purification
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Essential Oils
Basic, neutral | highly active | removal of terpenes
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Plant Extraction
Basic, neutral, acidic | highly active | isolation of active substances
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Dehydration of organic solvents
Basic | highly active | dehydration of organic solvents
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Enzymes
Neutral | highly active | purification
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Glycosides
Neutral | highly active | isolation of digitalis-, strophantus-glycosides, etc.
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Removal of Peroxides
Basic | highly active | from organic solvents
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Hormones
Neutral | highly active | isolation and purification of ketosteroids from neutral materials
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Purification of organic solvents
Basic | highly active | for technical purposes
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Oils
Basic | highly active | clarification of fatty oils, separation of fatty acids
Method Development
Aluminium oxide is also used as active layer in Thin-Layer Chromatography (TLC). TLC is a convenient and fast technique that most of the time provides complete separation of fairly complex mixtures. Any sample type that has been successfully separated by TLC on silica or alumina plates can be separated by means of liquid/solid chromatography. Mobile phase optimization using TLC can easily be carried out using the CAMAG® HPTLC Variosystem which allows a sample with six different mobile phases to be tested in parallel. The mobile phase composition established by means of TLC can be used for preparative chromatographic applications.
| Relative Humidity | % Water Added | Activ. Grade (Brockmann) | Rf of Dye |
|---|---|---|---|
| 0% | 0 | I | 0.15 |
| 3.4% | 3 | II | 0.22 |
| 7.5% | 6 | III | 0.33 |
| 20% | 10 | IV | 0.44 |
| 40% | 15 | V | 0.65 |
Brockmann Activity
Brockmann Activity is a measure for the water content of the Aluminium Oxide. Our standard Aluminium Oxide has the highest activity and lowest water content with a Brockmann Activity of I. Aluminium Oxide with a higher water content, having a Brockmann Activity of II – V, is also available.
High Quality
CAMAG does manufacture Aluminium Oxide since 1959 in Switzerland. The product, widely used in the pharmaceutical and chemical industries in purification processes, is of excellent quality. CAMAG has a comprehensive Quality System according to ISO 9001:2015 and is a REACH registered product.